Therefore, thyroid dysfunction and/or antibodies are relatively common during gestation ( 3, 4), and they have been thought to represent a risk to maternal and fetal health during pregnancy, although the results from different studies are controversial ( 3–5). Several changes are observed in maternal thyroid function during pregnancy, and failure to adapt to these physiological changes results in thyroid dysfunction ( 1), especially if complicated by the presence of thyroid antibodies ( 2). Pregnancy may serve as a glimpse into a woman’s future health because gestation presents many challenges for various organ systems. Overt hypothyroidism poses risk of diabetes. No association was found between thyroid dysfunction/antibodies and hypertension or overall mortality.Ĭonclusions: Thyroid dysfunction and antibodies during pregnancy seem to predict later thyroid disease. Subclinical hypothyroidism, TPO-Ab-positivity, and TG-Ab-positivity were also associated with later thyroid disease. Overt hypothyroidism was associated with subsequent maternal thyroid disease and diabetes. Results: Thyroid dysfunction and antibodies were not associated with pregnancy complications.
Main Outcome Measures: We focused on preeclampsia and gestational diabetes during index pregnancy, later maternal hypertension, diabetes, and thyroid disease morbidity and total mortality. Mothers were grouped and compared according to these test results. Participants: The study consisted of mothers of NFBC 1986 with early pregnancy serum samples for thyroid function and antibody analyses (n = 5805). Medication and hospital discharge records were used to assess maternal morbidity to hypertension, diabetes, and thyroid diseases. Objective: The aim of this study was to evaluate the association between maternal thyroid dysfunction/antibodies during pregnancy and pregnancy complications or later maternal hypertension, diabetes, and thyroid disease.ĭesign and Setting: We studied a prospective population-based cohort, Northern Finland Birth Cohort 1986 (NFBC 1986), with follow-up of 20 yr. Context: Knowledge is scarce concerning the significance of thyroid dysfunction/antibodies during pregnancy in regard to pregnancy complications/later maternal morbidity.
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